TRYPTYR activates the natural pathway
to increase tear production1
TRYPTYR activates the natural pathway
to increase tear production1
Click to see how TRYPTYR works
Role of TRPM8 receptors in natural tear production
The production of natural tears begins when tears evaporate, and temperature-sensitive ion channels, including transient receptor melastatin 8 (TRPM8) receptors, sense small temperature changes on the ocular surface.2,3
How TRYPTYR works
TRYPTYR is a TRPM8 receptor agonist. Studies in animals suggest that acoltremon, the active substance in TRYPTYR, is an agonist of TRPM8 receptors. Stimulation of TRMP8 receptors has been shown to activate trigeminal nerve signaling, leading to increased basal tear production. The exact mechanism of TRYPTYR in dry eye disease is unknown.1,4
See TRYPTYR in action
Statistically significant results
REFERENCES
- TRYPTYR. Prescribing Information. Alcon, Inc., 2025.
- Belmonte C, Gallar J. Cold thermoreceptors, unexpected players in tear production and ocular dryness sensations. Invest Ophthalmol Vis Sci. 2011;52(6):3888-3892.
- Yang S, Wu Y, Wang C, Jin X. Ocular surface ion-channels are closely related to dry eye: key research focus on innovative drugs for dry eye. Front Med (Lausanne). 2022;9:830853.
Bron AJ, de Paiva CS, Chauhan SK, et al. TFOS DEWS II pathophysiology report. Ocul Surf. 2017;15:438-510.
IMPORTANT SAFETY INFORMATION
Warnings and Precautions
Potential for Eye Injury and Contamination: To avoid the potential for eye injury and contamination, advise patients not to touch the vial tip to the eye or other surfaces.
INDICATIONS AND USAGE
TRYPTYR (acoltremon ophthalmic solution) 0.003% is indicated for the treatment of the signs and symptoms of dry eye disease (DED).
Use with Contact Lenses: TRYPTYR should not be administered while wearing contact lenses. If contact lenses are worn, they should be removed prior to administration of the solution. Lenses may be reinserted 15 minutes following administration.
Adverse Reactions
In clinical trials, the most common adverse reaction was instillation site pain (50%).
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.
Please click here for the TRYPTYR Full Prescribing Information.