Make more of your own natural tears with TRYPTYR

Patients’ tear production increased as early as Day 1

In clinical studies, TRYPTYR significantly increased natural tear production at Day 14, with results starting as early as Day 1.*

*TRYPTYR was studied in 2 clinical trials including 462 patients with dry eye disease over a 3-month period. An additional long-term safety study included 766 patients.

Symptom relief

Patients experienced dry eye relief as early as Day 28

A significant reduction in dry eye symptoms was reported by Day 28 in one clinical trial. A significant reduction was not observed at Day 28 in the second clinical trial.*

*TRYPTYR was studied in 2 clinical trials including 462 patients with dry eye disease over a 3-month period. An additional long-term safety study included 766 patients.

TRYPTYR stimulates tear production

TRYPTYR works differently than other eye drops by using your eyes’ natural processes to quickly make more of your own tears.

TRYPTYR stimulates the nerve and tear glands that produce the components of natural tears.

TRYPTYR was well tolerated

In clinical trials, the most common side effect of TRYPTYR was a burning or stinging sensation after applying the eye drop, reported in 50% of study patients. No serious side effects related to treatment with TRYPTYR were reported.

1.2%

reported burning or stinging

that was moderate or severe

0.7%

stopped treatment

due to burning or stinging sensation

<1 min

for most

In an additional safety study, 86% reported burning or stinging sensation lasting less than 1 minute

Ready to increase your natural tear production?

TAKING TRYPTYR STAY INFORMED

IMPORTANT SAFETY INFORMATION

Use TRYPTYR exactly as your healthcare provider tells you to.
TRYPTYR is for use in the eye. Each single-dose vial of TRYPTYR will give you enough medicine to treat both of your eyes. TRYPTYR vial is for 1-time use only. Use right away after opening and do not reuse.

What is TRYPTYR?

TRYPTYR (acoltremon ophthalmic solution) 0.003% is a prescription eye drop used for the treatment of the signs and symptoms of dry eye disease (DED).

• Keep the unopened single-dose vials in the original foil package until ready to use.

• Wash your hands before each use. Do not let the tip of the single-dose vial touch your eye or any other surface to avoid eye injury or infection.

• If you use TRYPTYR with other eye medicines, wait at least 5 minutes between using TRYPTYR and the other medicines.

• If you wear contact lenses, remove them before using TRYPTYR. Wait 15 minutes after dosing before putting contact lenses back in your eyes.

• Call your healthcare provider right away if you get an allergic reaction or other eye problems such as eye injury, eye infection, or eye pain.

• The most common side effect of TRYPTYR in clinical trials was burning or stinging sensation in the eye upon instillation, which was reported in 50% of patients.

For additional information about TRYPTYR, talk to your healthcare provider and click here to see the full Prescribing Information.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.