How do I use TRYPTYR^®?

Narrator: How to use TRYPTYR eye drops. 
On-screen text: How to Use
TRYPTYR^® (acoltremon ophthalmic solution) 0.003%
Narrator: If your doctor has prescribed TRYPTYR, here’s how you can add it to your daily routine and get the most out of your treatment. 
On-screen text: What is TRYPTYR?
TRYPTYR (acoltremon ophthalmic solution) 0.003% is a prescription eye drop used for the treatment of the signs and symptoms of dry eye disease (DED).
This video does not take the place of talking to your healthcare provider about dry eye or your treatment. 
Narrator: TRYPTYR works fast to stimulate your eyes’ natural ability to make more of your own tears as early as Day 1. 
On-screen text: More of your own natural tears starting as early as Day 1*
*In clinical studies, TRYPTYR significantly increased natural tear production at Day 14, with results starting as early as Day 1 and sustained over time (90 days).  
Narrator: That's why TRYPTYR is a treatment designed to fit into your everyday routines, like brushing your teeth, hair, or moisturizing. 
On-screen text: ✓ Fits into everyday routines
NOT AN ACTUAL PATIENT. 
Narrator: First, it begins with applying TRYPTYR correctly, so you can get the most out of taking TRYPTYR day after day. 
On-screen text: ! Note: Unopened cartons need to be stored in fridge until opened 
Narrator: Now it's your TRYPTYR Time—your time to activate relief by making more of your own natural tears. 
On-screen text: TRYPTYR Time
Narrator: It's simple: just one drop in each eye, twice a day, 12 hours apart.
On-screen text:  TRYPTYR Time
[eye icon] 1 drop PER EYE x [clock icon] Twice daily 12 HOURS APART
Narrator: To get ready, wash your hands and remove contacts if you're wearing them.  Simply pull one single-dose vial from the strip.
On-screen text: ✓ Unwrap the foil pouch and tear off just 1 vial
Narrator: Each vial will have enough TRYPTYR for both eyes. 
On-screen text: ✓ Use the same vial for both eyes 
✓ Put other vials back into carton
Narrator: Keep the vial held upright and now open it by twisting off the tab. 
On-screen text: ✓ Twist off the tab 
Narrator: Now tilt your head back, gently pull your lower eyelid downwards and look up. Some people may find having a mirror in front of them to be helpful.
On-screen text: ! Pro tip: Using a mirror helps some with application 
Narrator: Place the tip of the vial close to your eye, but do not let it touch your eye.
Narrator: Gently squeeze the vial and let one full drop of TRYPTYR coat your eye, then gently close your eye for a few seconds. You then use the same vial to apply one drop to your other eye, the same way, keeping your head tilted back and your eyelid held down.  
You may feel a sensation. In clinical trials, half of patients using TRYPTYR reported burning or stinging. 1.2% reported it as moderate or severe. In another safety study, where they measured the duration, 86% of patients experiencing burning or stinging reported it lasted a minute or less. 
On-screen text: In clinical trials including 766 patients, half the patients using TRYPTYR reported burning or stinging 
[eye icon] 1.2% of people reported it was moderate or severe
[clock icon] In another study in which 182 patients used TRYPTYR, 86% of the patients that experienced burning or stinging said it lasted 1 minute or less  
Narrator: After you have applied a drop to both eyes, discard the single-use vial, even if there is remaining liquid inside. 
On-screen text: [trash can icon] Discard the single-use vial after application
Narrator: TRYPTYR is preservative-free, meaning once it's opened, it can only be used once. 
On-screen text: [vial icon] Only use the vial 1x
Narrator: After applying TRYPTYR, wait at least 5 minutes if you're applying other eye drops,
On-screen text: [clock icon] 5 minutes
✓ Wait 5 minutes if applying other eye drops
Narrator: and wait 15 minutes before placing contacts back in if you wear them. 
On-screen text: [clock icon] 15 minutes
✓ Wait 15 minutes before putting contacts back in
Narrator: Call your healthcare provider right away if you experience an allergic reaction or other eye problems such as eye injury, eye infection, or eye pain
On-screen text: Call your healthcare provider right away if you experience an allergic reaction or other eye problems such as eye injury, eye infection, or eye pain.
Narrator: Store unopened cartons in a refrigerator. After opening the carton, TRYPTYR may be kept refrigerated or at room temperature. If stored at room temperature, TRYPTYR should be used within 30 days. 
On-screen text: ✓ Keep unopened cartons in the refrigerator
Narrator:  Do not use past the expiration date printed on the carton and foil pouch. 
On-screen text: X Do not use past the expiration date
Narrator:  After opening each foil pouch, the single-use vial should be used within 7 days.
On-screen text:  ✓ Store unopened vials in the original foil pouch until ready for use
Narrator: Do not use past the expiration date on the vial.
On-screen text: ! Pro tip: Use before putting on makeup 
Narrator: And that's it—now you know how to make TRYPTYR Time part of your daily routine and get the most out of your dry eye treatment. 
On-screen text: Your TRYPTYR Time can be part of your daily routine
Narrator: Remember, it's just one drop of TRYPTYR in each eye, twice daily, about 12 hours apart. 
On-screen text: [eye icon] 1 drop PER EYE x [clock icon] Twice daily 12 HOURS APART
Narrator: Dry eye is a chronic condition. Talk to your doctor about the importance of using TRYPTYR as prescribed, even when symptoms improve.
Narrator & On-screen text: IMPORTANT SAFETY INFORMATION
 

• Use TRYPTYR exactly as your healthcare provider tells you to.

• TRYPTYR is for use in the eye. Each single-dose vial of TRYPTYR will give you enough medicine to treat both of your eyes. TRYPTYR vial is for 1-time use only. Use right away after opening and do not reuse.

• Keep the unopened single-dose vials in the original foil package until ready to use.

• Wash your hands before each use. Do not let the tip of the single-dose vial touch your eye or any other surface to avoid eye injury or infection.

• If you use TRYPTYR with other eye medicines, wait at least 5 minutes between using TRYPTYR and the other medicines.

• If you wear contact lenses, remove them before using TRYPTYR. Wait 15 minutes after dosing before putting contact lenses back in your eyes.

• Call your healthcare provider right away if you get an allergic reaction or other eye problems such as eye injury, eye infection, or eye pain.

• The most common side effect of TRYPTYR in clinical trials was burning or stinging sensation in the eye upon instillation, which was reported in 50% of patients.

   

For additional information about TRYPTYR, talk to your healthcare provider or see the Full Prescribing Information at .com. 
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.